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  • Title: Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats.
    Author: Lijinsky W, Reuber MD, Blackwell BN.
    Journal: J Natl Cancer Inst; 1980 Aug; 65(2):451-3. PubMed ID: 6931260.
    Abstract:
    Three nitrosotrialkylureas were administered to female F344 rats as approximately 1-mM solutions in drinking water. Nitrosotrimethylurea, given for 47 weeks, gave rise to astrocytomas of the brain and tumors of the forestomach; nitrosotriethylurea induced a high incidence of adenocarcinomas of the breast and uterus and tumors of the forestomach. Nitrosomethyldiethylurea induced almost exclusively a high incidence of both astrocytomas of the brain and tumors of the spinal cord.
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