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  • Title: Acute renal tubular dysfunction following cis-dichlorodiammine platinum therapy.
    Author: Davis S, Kessler W, Haddad BM, Maesaka JK.
    Journal: J Med; 1980; 11(2-3):133-41. PubMed ID: 6931873.
    Abstract:
    Following single, high dose (3 mg/kg) DDP therapy seven patients with head and neck cancer developed significant serum electrolyte disturbances. Hypocalcemia, hypomagnesemia, hypokalemia, and hypophosphatemia were the most clinically significant electrolyte abnormalities. Renal clearance studies support a pathologic mechanism of a diffuse renal tubular leakage not associated with renal failure.
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