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  • Title: Effect of age on antipyrine metabolism in patients with gastric cancer.
    Author: Higuchi T, Nakamura T, Uchino H.
    Journal: J Natl Cancer Inst; 1980 Nov; 65(5):897-900. PubMed ID: 6933259.
    Abstract:
    The metabolism of antipyrine was studied in 19 male patients with gastric cancer. Three groups of subjects were chosen for the study: 4 patients 46--51 years of age (group 1), 8 patients 52--61 years old (group 2), and 7 patients 62--75 years old (group 3) matched for sex, smoking, alcohol intake, renal function, and liver function. The mean half-life (t 1/2) of antipyrine in group 3 (15.6 +/- 4.8 hr) was significantly longer than that in group 1 (8.1 +/- 0.9 hr, P < 0.01). Similarly, the mean metabolic clearance rate (MCR) in group 3 (246 +/- 78 ml/hr/kg) was significantly lower than that in group 1 (498 +/- 175 ml/hr/kg, P < 0.02). Significant correlations were observed between age and the t 1/2 of antipyrine (r = 0.592, P < 0.01) and between age and MCR (r = -0.499, P < 0.05). The plasma of 8 patients was tested for testosterone levels. Significant correlations were observed between plasma testosterone levels and both the t 1/2 of antipyrine (4 = -0.783, P < 0.05) and MCR (r = 0.912, P < 0.001). These observations indicate that drug-metabolizing ability might decline with age in cancer patients.
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