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  • Title: [Cytogenetic findings in habitual abortion. Chromosomal analysis in 123 couples (author's transl)].
    Author: Husslein P, Schnedl W, Wagenbichler P.
    Journal: Wien Klin Wochenschr; 1980 Aug 29; 92(16):575-8. PubMed ID: 6933750.
    Abstract:
    From the 1st of April 1974 till the 30th of September 1979 a consecutive series of 123 couples with a history of recurrent abortion was studied cytogenetically with modern banding techniques. 8 chromosomal aberrations were detected (6.5%); 3 women were found to be balanced reciprocal translocation carriers; the karyotype of 3 women and one man showed a pericentric inversion, one women was found to be a mosaic for 46 XX/45 X0. It is concluded from the results of this report that cytogenetic evaluation is indicated in cases of habitual abortion. The expected rate of chromosomal aberrations is especially high in couples with a mixed history of abortions, intrauterine fetal deaths and malformations. In case a chromosomal aberration is detected the patients have to be counselled individually according to the type of anomaly.
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