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  • Title: Single intravenous dose kinetics accumulation of atenolol in patients with impaired renal function and on hemodialysis.
    Author: Kirch W, Schäfer M, Braun M.
    Journal: Arch Toxicol Suppl; 1980; 4():366-9. PubMed ID: 6933939.
    Abstract:
    The concentration of atenolol in plasma and urine was determined following an intravenous (i.v.) dose given to 17 hypertensive patients with a glomerular filtration rate (GFR) between 5 and 105 ml/min and in 4 patients on hemodialysis. In patients with normal renal function the mean half life of elimination was calculated to be 6.8 h. This value increased to a mean of 50.1 h in patients with a GFR below 10 ml/min. In patients on hemodialysis the half life of elimination was about 4 h. The elimination rate constants as well as the body and renal clearances of atenolol have a significant correlation with the GFR. Although accumulation of atenolol was observed, especially after multiple oral doses and in patients with a GFR below 30 ml/min, no toxic side effects occurred.
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