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  • Title: Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase.
    Author: Backer JM, Dawidowicz EA.
    Journal: J Biol Chem; 1981 Jan 25; 256(2):586-8. PubMed ID: 6935193.
    Abstract:
    Greater than 90% of the cholesterol in small unilamellar vesicles composed of egg lecithin and cholesterol (molar ratio 1:0.7) was oxidized by a cholesterol oxidase from Brevibacterium sp., with a single time constant and a half-time of 1 min at 37 degrees C. The enzyme preparation used was at least 95% pure and possessed no detectable phospholipase C activity. Since cholesterol is present in both halves of the bilayer, it was concluded that transmembrane movement of cholesterol in these vesicles occurs with a half-time of 1 min or less at 37 degrees C.
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