These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Changes in sensitivity to cyclophosphamide of mouse mammary tumors during serial transplantation.
    Author: Sluyser M, De Goeij CC, Evers SG.
    Journal: J Natl Cancer Inst; 1981 Feb; 66(2):327-30. PubMed ID: 6935481.
    Abstract:
    The effect of the cytostatic agent cyclophosphamide on the growth of several transplant generations of a GRS/A mouse mammary tumor line was studied. Cyclophosphamide caused more growth inhibition in transplant generation 6 than in other transplant generations. Transplant generation 6 represented the time of transition in the tumor line from hormone responsiveness to hormone independence. These results suggest that mammary tumors are especially sensitive to chemotherapy at the stage when the first hormone-independent cells appear in the tumor.
    [Abstract] [Full Text] [Related] [New Search]