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  • Title: Adult celiac disease associated with HLA-DRw3 and -DRw7.
    Author: Betuel H, Gebuhrer L, Descos L, Percebois H, Minaire Y, Bertrand J.
    Journal: Tissue Antigens; 1980 Mar; 15(3):231-8. PubMed ID: 6936866.
    Abstract:
    Celiac disease (CD), which occurs in Europe with varying frequency, is known to be associated with HLA-B8 and even more strongly with HLA-Dw3 because of the high linkage disequilibrium between these two antigens. After typing for HLA-A, -B and -DR antigens in adult patients with CD, we can confirm the high prevalence of B8 (72.7%) and of DRw3 (63.7%). However we find that DRw7 is also significantly increased (54.5%); DRw3 and DRw7, taken together, represent 86% of our 22 patients.
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