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  • Title: Cellular response to orthodontic force.
    Author: Roberts WE, Goodwin WC, Heiner SR.
    Journal: Dent Clin North Am; 1981 Jan; 25(1):3-17. PubMed ID: 6937399.
    Abstract:
    Orthodontic force systems, by way of stress/strain, are transduced to a biologic signal that affects a multifaceted bone remodeling response. Tooth movement involves not only a periodontal ligament response (alveolus translocation), but also bursts of resorption associated with truncated remodeling events in the path of the advancing tooth. Osteoclasts are recruited primarily from the macrophage/monocyte series, whereas osteoblasts are produced by local periodontal ligament cell proliferation and differentiation. Based on nuclear size, periodontal cells are a multicompartmental population. The relatively large nuclei (D fraction) are the immediate precursors of osteoblasts, and the cells with small nuclei (A fraction are apparently the undifferentiated, germinal compartment.
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