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  • Title: Conjugation of catecholamines, a variable to be accounted for in human hypertension.
    Author: Kuchel O, Buu NT, Hamet P, Larochelle P, Genest J.
    Journal: Prog Biochem Pharmacol; 1980; 17():66-74. PubMed ID: 6937881.
    Abstract:
    A subgroup of essential hypertensive (EH) patients with high sympathetic tone had low plasma conjugated norepinephrine (NE) and epinephrine (E), but elevated free NE and E and a hyperresponsiveness to various stimuli to the autonomic nervous system. Pheochromocytoma patients could also be divided according to conjugated NE + E levels, this time into normal and elevated conjugated groups. The latter seem to be somewhat protected by the conjugation, showing less free NE and E 'flooding' during hypertensive crises and lower VMA excretion. The degree of catecholamine conjugation can thus modify the sympathetic tone in hypertension.
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