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  • Title: Aminoglycoside nephrotoxicity in dogs: dependence on drug, dose and regimen.
    Author: Thompson WL, Powell S.
    Journal: Scand J Infect Dis Suppl; 1980; Suppl 23():91-5. PubMed ID: 6937972.
    Abstract:
    In female mongrel dogs nephrotoxicity of three aminoglycosides (gentamicin, tobramycin and netilmicin) was compared with relation to the cortical aminoglycoside concentration. A standard regimen of 45 mg/kg/day with constant intravenous infusion and once daily dosing of each aminoglycoside was used, and in subsequent dogs netilmicin daily dose was increased to an average of 73 mg/kg/day.
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