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  • Title: Penicillamine and the SLE syndrome.
    Author: Walshe JM.
    Journal: J Rheumatol Suppl; 1981; 7():155-60. PubMed ID: 6939878.
    Abstract:
    Penicillamine-induced systemic lupus erythematosus (SLE) and penicillamine-immune complex nephritis are histologically and serologically distinct. One hundred and twenty patients with Wilson's disease treated with penicillamine have been analyzed. Eight developed the serologic changes of SLE; in 4, it was necessary to discontinue treatment. In addition, 6 patients developed immune complex nephritis, which necessitated discontinuing treatment. All but 1 have since been managed on triethylene tetramine 2HCl (Trien).
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