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  • Title: Proteinuria in D-penicillamine-treated rheumatoid arthritis.
    Author: Crawhall JC.
    Journal: J Rheumatol Suppl; 1981; 7():161-3. PubMed ID: 6939879.
    Abstract:
    The incidence of proteinuria in D-penicillamine-treated rheumatoid arthritis has been between 10% and 20% in the 1st year of therapy; afterward, few develop proteinuria. Incidence is related to both quantity of penicillamine administered and inherent response variability. About 1/3 of those with proteinuria may proceed to a nephrotic syndrome if therapy is continued. Light microscopy of renal biopsy tissue shows only minimal glomerular changes. Electron microscopy reveals sub-epithelial electron-dense deposits and fusion of epithelial cell processes. Immunofluorescence microscopy demonstrates granular capillary wall deposits of IgG and C3.
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