These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. An endoscopic assessment.
    Author: Morris AD, Holt SD, Silvoso GR, Hewitt J, Tatum W, Grandione J, Butt JH, Ivey KJ.
    Journal: Scand J Gastroenterol Suppl; 1981; 67():131-5. PubMed ID: 6941392.
    Abstract:
    A prospective endoscopic study was carried out in 65 patients with rheumatoid arthritis to assess the prevalence of gastroduodenal lesions on aspirin alone or aspirin plus another anti-inflammatory drug (n = 26). All patients were taking greater than or equal to 8 tablets aspirin/day for greater than or equal to 3 months. Drug therapy consisted of regular, buffered or enteric-coated aspirin +/- one other non-steroidal anti-inflammatory drug or less than or equal to 10 mg prednisone/day. Endoscopic findings were graded as normal, or gastric and/or duodenal erythema, erosions, or ulcer; only the most serious lesion was tabulated. Fifty-three percent of patients on aspirin alone has a gastric ulcer or erosions, and 13% duodenal ulcer or erosions compared to 35% with gastric lesions and 4% with duodenal lesions on aspirin plus a second drug. Twenty-two percent of patients taking regular aspirin had gastric ulcers compared to only 6% taking enteric coated. Patients on enteric coated aspirin and prednisone had only a 10% prevalence of severe gastro-duodenal lesions. In conclusion, the combination of a second anti-inflammatory drug and aspirin therapy did not result in a higher prevalence of gastro-duodenal damage over that produced by aspirin therapy alone. Enteric coated aspirin produced significantly fewer serious lesions than regular or buffered aspirin. The combination of enteric-coated aspirin plus low dose prednisone caused a low prevalence of severe gastro-duodenal lesions.
    [Abstract] [Full Text] [Related] [New Search]