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  • Title: Chemical modification of anthracycline antibiotics. I. Demethoxycarbonylation, 10-epimerization and 4-o-methylation of aclacinomycin A.
    Author: Tanaka H, Yoshioka T, Shimauchi Y, Matsuzawa Y, Oki T, Inui T.
    Journal: J Antibiot (Tokyo); 1980 Nov; 33(11):1323-30. PubMed ID: 6941951.
    Abstract:
    Demethoxycarbonyl derivatives of aclacinomycin A and of its 7-epimer, 10-epi-aclacinomycin A and 4-O-methylaclacinomycin A were chemically derived from aclacinomycin A. The cytotoxicity and inhibitory effects of RNA and DNA synthesis in cultured L1210 leukemia cells of the 4-O-methyl derivative approximated that of aclacinomycin A, while the demethoxycarbonyl derivatives and 10-epi-aclacinomycin A exhibited decreased activities in comparison with the parent compound.
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