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  • Title: Isochromosome (17q) in Philadelphia chromosome (Ph1)-negative juvenile chronic myelocytic leukemia.
    Author: Casalone R, Francesconi D, Pasquali F, Comotti B, Vaccari F.
    Journal: Cancer Genet Cytogenet; 1981 Mar; 3(2):145-8. PubMed ID: 6944155.
    Abstract:
    A dicentric isochromosome of the long arm of one chromosome #17 was the only abnormality present in a 12-year-old boy with Philadelphia chromosome (Ph1)-negative juvenile chronic myelocytic leukemia. This association does not seem to have been reported in the literature. It is postulated that the finding of an isochromosome (17q) may also have a negative prognostic value in the Ph1-negative type of chronic myelogenous leukemia.
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