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  • Title: Self-renewal capacity of leukemic blast progenitor cells.
    Author: Buick RN, Chang LJ, Messner HA, Curtis JE, McCulloch EA.
    Journal: Cancer Res; 1981 Nov; 41(11 Pt 2):4849-52. PubMed ID: 6945908.
    Abstract:
    A review is presented of experimental information pertaining to the characteristics of a procedure designed to quantitate the capacity for self-renewal in clonogenic cells of human acute myeloblastic leukemia. In a series of 44 previously untreated patients, a significant correlation (p less than 0.01) was seen between low capacity for self-renewal and successful remission induction. Three cytotoxic drugs (Adriamycin, 1-beta-D-arabinofuranosylcytosine, and N-[4-(19-acridinylamino)-3-methoxyphenyl]-methanesulfonamide) were tested for preferential effect against self-renewal events. Surviving clonogenic cells to these agents had, respectively, unchanged, lower, and higher capacity for self-renewal. The implications of such drug properties are discussed.
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