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  • Title: Increased ammonia production during forearm ischemic work test in McArdle's disease.
    Author: Rumpf KW, Wagner H, Kaiser H, Meinck HM, Goebel HH, Scheler F.
    Journal: Klin Wochenschr; 1981 Dec 01; 59(23):1319-20. PubMed ID: 6947119.
    Abstract:
    A patient with typical features of late onset McArdle's disease is described. During forearm ischemic work test the patient exhibited an exaggerated increase in ammonia release, largely exceeding normal values. It is suggested, that this is due to an activation of the myokinase/myoadenylate deaminase pathway. Besides lack of lactate release increased ammonia release during ischemia may be a typical feature of McArdle's disease.
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