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  • Title: Prevention of blastic crisis in Ph1-positive chronic myeloid leukemia.
    Author: Sharp JC.
    Journal: Recent Results Cancer Res; 1982; 80():78-82. PubMed ID: 6949238.
    Abstract:
    Fourteen untreated patients with Ph1-positive myeloid leukaemia received combination chemotherapy consisting of blocks of doxorubicin, vincristine, cytosine arabinoside and 6-thioguanine. Significant karyotypic conversion occurred in six patients, the percentage of Ph1-positive cells in the bone marrow falling by at least 50%. Maintenance therapy comprised vincristine, busulphan, hydroxyurea, 6-mercaptopurine and dibromannitol in rotation. Reinduction therapy was administered when Ph1 positivity reverted to 100%. Karyotypic reconversion was achieved in three of four patients. After induction, chromosome analysis of the bone marrow was performed every 3-6 months to detect the appearance of aneuploid clones, the intention being to intensify therapy at that stage.
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