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  • Title: Prophylactic treatment of the central nervous system in acute lymphoblastic leukemia. CT findings in 45 children off therapy.
    Author: Scotti G, Bracchi M, Masera G, Auriti L, De Grandi C, Uderzo C.
    Journal: Ital J Neurol Sci; 1981 Dec; 2(4):361-5. PubMed ID: 6949881.
    Abstract:
    45 children with ALL treated with intrathecal Methotrexate and radiation therapy, all in hematologic remission, have been examined with brain CT at intervals varying from 3 to 6 years after completion of CNS prophylaxis. Abnormalities were detected in 20% of the children; the main findings were: calcifications within the brain parenchyma in 3 patients; enlargement of the ventricular system and/or sulci in 8. The 3 patients with calcifications had seizures during or after treatment whereas those with dilatation of the ventricular system or sulci presented no neurological signs.
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