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  • Title: Cellular pharmacokinetics of aclacinomycin A in cultured L1210 cells. Comparison with daunorubicin and doxorubicin.
    Author: Zenebergh A, Baurain R, Trouet A.
    Journal: Cancer Chemother Pharmacol; 1982; 8(2):243-9. PubMed ID: 6955072.
    Abstract:
    Aclacinomycin, which is more lipophilic than daunorubicin and doxorubicin, is taken up and released more rapidly and extensively by L1210 cells. After 5 h of incubation 91% of aclacinomycin is found in the nuclei of L1210 cells and the drug present in the post-nuclear fraction is distributed between the lysosomes and the cytosol. After an incubation of 5 h aclacinomycin decreases the density of the lysosomes. This effect is not observed either with doxorubicin or daunorubicin or when the cells are incubated with aclacinomycin for only 30 min.
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