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  • Title: Vincristine and prednisolone therapy in blast crisis of chronic myelogenous leukaemia in childhood.
    Author: Kano Y, Takaku F, Sakamoto S, Hida K, Kasahara T, Okamura J, Hasegawa K, Tsukada T, Sasaki H.
    Journal: Scand J Haematol; 1981 Nov; 27(5):323-6. PubMed ID: 6955938.
    Abstract:
    6 cases of chronic myelogenous leukaemia (CML) blast crisis in childhood were treated with vincristine and prednisolone (V-P). In 3 terminal transferase ((TdT)-positive cases, blast cells were lymphoid in appearance. All 3 TdT-positive patients entered a complete remission but developed meningeal leukaemia. The mean duration of survival from the onset of blast crisis was 32 months. In 3 TdT-negative cases, V-P therapy was ineffective. The results of this study suggest that V-P therapy is more effective for CML blast crisis in childhood with TdT positive blast cells and that prophylactic central nervous system treatment is necessary to prevent meningeal leukaemia.
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