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  • Title: Carcinogenicity test of acetoxime in MRC-Wistar rats.
    Author: Mirvish SS, Salmasi S, Runge RG.
    Journal: J Natl Cancer Inst; 1982 Oct; 69(4):961-2. PubMed ID: 6956769.
    Abstract:
    Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. The dose of 1.0 g/liter was administered 5 days/week for 18 months (total dose, 6.2--7.0 g/rat). The test compound induced benign hepatocellular adenomas in 80% of the males but did not produce tumors in the females. This is the first report that oximes, which are fairly widely used in industry, are tumorigenic.
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