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  • Title: Histochemistry of the 3 beta-hydroxysteroid, 17 beta-hydroxysteroid and 3 alpha-hydroxysteroid dehydrogenases in human salivary glands.
    Author: Sirigu P, Cossu M, Perra MT, Puxeddu P.
    Journal: Arch Oral Biol; 1982; 27(7):547-51. PubMed ID: 6957169.
    Abstract:
    Human parotid and submandibular glands showed no 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity. The 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) and the 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) appeared intensely reactive in the duct epithelia of the male and female glands and weakly reactive in the acinar cells of the female ones. The failure to demonstrate 3 alpha-HSD activity indicates that in-vivo androgen activation, if present at all, is not so marked as in target organs. The different distribution of the 3 beta-HSD and 17 beta-HSD in the two sexes can be related not only to the oxidation of androgens but also to the metabolism of the female hormones. Glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) do not seem to be specifically influenced by the sex hormones as their pattern of distribution showed no sex differences.
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