These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of age on circulating 6-keto-prostaglandin F1 alpha in humans.
    Author: Ylikorkala O, Osterman T, Lindén IB, Viinikka L.
    Journal: Prostaglandins Leukot Med; 1982 Nov; 9(5):569-75. PubMed ID: 6960379.
    Abstract:
    The effect of age on the production of the antiaggregatory prostacyclin (PGI2) was studied by measuring 6-keto-PGF1 alpha in the plasma of 140 subjects (50 males and 90 females) between 10-90 years of age. The 6-keto-PGF1 alpha concentrations (mean +/- SD) in subjects between 10-20 years of age were higher (126 +/- 63 pg/ml, n = 24) than the levels in subjects between 21-30 years of age (88 +/- 30 pg/ml, n = 16), or in subjects between 51-70 years of age (88 +/- 30 pg/ml, n = 17), whereas in subjects between 71-90 years of age, the 6-keto-PGF1 alpha levels 100 +/- 59 pg/ml, n = 36) did not differ from those in subjects under 20 years of age. The 6-keto-PGF1 alpha levels in women over 70 years (118 +/- 66 pg/ml, n = 20) were higher (p = less than 0.05) than those in men of the same age (78 +/- 42 pg/ml, n = 16), but no other sex-related connections in 6-keto-PGF1 alpha concentrations were seen. Our data suggest that the PGI2 generation in vivo, as measured by 6-keto-PGF1 alpha levels in peripheral plasma, is higher in adolescence and elderly females than in the healthy adults.
    [Abstract] [Full Text] [Related] [New Search]