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  • Title: Focal nodular hyperplasia of the liver and contraceptive steroids.
    Author: St Omer FB, Iozzo RV, Casetti P, Dellarolle AC.
    Journal: Acta Hepatogastroenterol (Stuttg); 1978 Aug; 25(4):319-21. PubMed ID: 696209.
    Abstract:
    A case of Focal Nodular Hyperplasia of the liver in a young woman taking oral contraceptives is described. The parenteral administration of an elevated dosage of progesterone in a concentrated period of time is a remarkable feature of this case. The vascular alterations, which consisted of a marked increase of arterial and venous formations, intimal proliferation, diffused thrombosis, and the presence of large blood spaces recalling "peliosis hepatis" are the most salient microscopic findings. We should not exclude the possibility that these peculiar vascular alterations be the real effect of steroid hormones on a pre-existent hepatic lesion. A case of focal nodular hyperplasia (FNH) of the liver in a 25-year-old woman taking oral contraceptives is reported. The patient had taken Lyndiol for 6 months (1975) and had received 6 injections of 5 mg benzoate estradiol plus 50 mg progesterone at intervals of about 2 months (January 1974-February 1976). An isolated mass was found in the right hepatic lobe. The microscopic findings corresponded to FNH. The vascular alterations consisted of a marked increase of arterial and venous formations, intimal proliferation, diffused thrombosis, and the presence of large blood spaces. The possibility that these vascular alterations be the real effect of steroid hormones on a preexistent hepatic lesion should not be excluded.
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