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  • Title: Choline acetyltransferase activity in postganglionic parasympathetic nerves after "pharmacological decentralization".
    Author: Ekström J, Lindmark B.
    Journal: Acta Pharmacol Toxicol (Copenh); 1978 Aug; 43(2):103-10. PubMed ID: 696339.
    Abstract:
    The ganglion blocking drug chlorisondamine given frequently and in gradually increasing doses over a period of time to adult rats causes the activity of choline acetyltransferase to fall in the postganglionic parasympathetic nerves of parotid glands. Such a "pharmacologically" decentralized gland was also found to have lost weight and to have developed a supersensitivity to chemical stimuli. All these phenomena are thought to be consequences of loss or reduction of secretory impulses from the central nervous system due to impaired ganglionic transmission.
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