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  • Title: The role of insulin in the response of murine T lymphocytes to mitogenic stimulation in vitro.
    Author: Snow EC, Feldbush TL, Oaks JA.
    Journal: J Immunol; 1980 Feb; 124(2):739-44. PubMed ID: 6965389.
    Abstract:
    The ability of insulin to influence the responsiveness of murine T lymphocytes in a culture system containing a serum substitute was documented. The presence of insulin was found to enhance the concanavalin A (Con A) reactivity of the lymphocytes. Once the cells were activated by a short-term exposure to Con A, insulin was capable of replacing Con A for the continued stimulation of the cells. This was true both for lymphocyte proliferation and for the generation of nonspecific cytotoxic T lymphocytes. The presence or absence of insulin was not found to influence the phytohemagglutinin responsiveness of the T lymphocytes. Possible reasons for the observed results are discussed in relation to a proposed model for lymphocyte activation.
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