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  • Title: Immunologic function in patients with carcinoma of the pancreas.
    Author: Fortner JG, Kim DK, Hopkins L, Barrett MK, Pinsky CM, Day NK.
    Journal: Surg Gynecol Obstet; 1980 Feb; 150(2):215-8. PubMed ID: 6965431.
    Abstract:
    The immune fuction of 41 patients with duct cell adenocarcinoma of the pancreas or carcinoma of the periampullary region was studied by skin testing with 2,4-dinitrocholorobenzene and common microbial antigens, in vitro lymphocyte reactivity to mitogens, T-lymphocyte and B-lymphocyte cell counts and measurements of complement levels. Results show that a great proportion of patients had depressed immune function. Depression is particularly severe in lymphocyte reactivity. Positive response to skin tests with a microbial antigen carries a slightly better prognosis. The complement level is usually normal or elevated. Correlation between immune function, prognosis and tumor resectability in individual patients is generally poor.
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