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  • Title: Acquired von Willebrand's syndrome during autoimmune disorder.
    Author: Pizzuto J, Ambriz R, de la Paz Reyna M, Monrroy LM, Morales MR, Aviles A, Conte G, Enriquez R.
    Journal: Thromb Haemost; 1980 Feb 29; 42(5):1523-8. PubMed ID: 6966081.
    Abstract:
    A case with evidence of acquired von Willebrand's syndrome associated with systemic lupus erythmatosus and Sjögren's syndrome is described. The patient, who had no family history of bleeding, presented a haemorrhagic diathesis of recent origin, the bleeding time was prolonged, procoagulant Factor-VIII and von Willebrand factor levels were low and platelet aggregation was decreased with different concentrations of Ristocetin. No improvement was seen after the tranfusion of cryoprecipitates, and there was no increase in procoagulant Factor-VIII. Clinical improvement resulted after treatment with corticosteroids, and later, the laboratory abnormalities characteristic of von Willebrand's disease became normal. The level of procoagulant factor-VIII reached the very high level of 810%.
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