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  • Title: Increase in T gamma lymphocytes in B-cell chronic lymphocytic leukaemia.
    Author: Lauria F, Foa R, Catovsky D.
    Journal: Scand J Haematol; 1980 Feb; 24(2):187-90. PubMed ID: 6966421.
    Abstract:
    A significant increase in the proportion (mean 38% +/- 9.3 SD) and absolute number of T gamma (suppressor) lymphocytes was observed in 13 patients with chronic lymphocytic leukaemia (CLL) compared with 20 normal controls (mean 19% +/- 6.5). Conversely, the proportion of T mu (helper) lymphocytes was lower in CLL (mean 27% +/- 9.3) than in the controls (mean 40% +/- 4), although the absolute numbers were normal or increased. It is suggested that an imbalance of T-lymphocyte subsets controlling B-lymphocyte differentiation may be relevant in the pathogenesis of CLL or some of its associated features.
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