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  • Title: [Activation of the anticoagulant system by prethrombin 2, a thrombin precursor].
    Author: Strukova SM, Umarova BA, Gribkova NN, Kudriashov BA.
    Journal: Biull Eksp Biol Med; 1980 Mar; 89(3):270-2. PubMed ID: 6966943.
    Abstract:
    Prethrombin 2, and immediate precursor of thrombin, was obtained by limited trypsin or active factor X proteolysis by prethrombin 1. The conversion of prethrombin 1 to prethrombin 2 does not occur in the absence of enzymes. It has been shown that factor V has no influence on the rate of thrombin generation from prethrombin 2 and that prethrombin itself has no coagulant or esterase activity. Intravenous injection of prethrombin 2 preparations led to an increase in plasma recalcification time, overall fibrinolytic activity and non-enzymatic fibrinolysis. In addition, there was observed a considerable increase in fibrinogen-heparin complex activity. The data obtained indicate excitation of the anticoagulant system with intravenous injection of small doses of prethrombin 2.
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