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  • Title: Meningitis due to Haemophilus influenzae type b resistant to both ampicillin and chloramphenicol.
    Author: Kenny JF, Isburg CD, Michaels RH.
    Journal: Pediatrics; 1980 Jul; 66(1):14-6. PubMed ID: 6967583.
    Abstract:
    A strain of Haemophilus influenzae type b with considerable resistant to both ampicillin and chloramphenicol was recovered from a South Dakota child with meningitis. There was an initial lack of response to conventional doses but the child improved after a brief period of 200 mg/kg/day of chloramphenicol. The organism showed in vitro resistance to ampicillin, carbenicillin, tetracycline, and chloramphenicol (for each antibiotic the minimal inhibitory concentration (MIC) was 8 micrograms/ml or greater with a bacterial challenge of 10(5) colony-forming units (CFU)/ml), but it was sensitive to both streptomycin and rifampin (MIC 1.6 micrograms/ml, respectively). Isobolograms constructed from the results of testing various concentrations of ampicillin and chloramphenicol showed additive effects with high bacterial inocula (10(5) or 10(7) CFU/ml), but antagonism with low inocula (10(2) or 10(4) CFU/ml).
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