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  • Title: [Effect of antiserum against isologous aggregated immunoglobulins on synthesis of nonspecific immunoglobulins in mice immunized with sheep erythrocytes].
    Author: Chernousova LN, Sidorova EV, Kul'berg AIa.
    Journal: Biull Eksp Biol Med; 1980 Jul; 89(7):69-70. PubMed ID: 6967742.
    Abstract:
    Injection of antiserum against isologous aggregated immunoglobulins into mice immunized with sheep red blood cells (5X10(7)) suppressed by 20% on the average the synthesis of nonspecific immunoglobulins. Concurrently the antiserum caused a 70% decrease in the amount of rosette-forming cells, but did not affect the proliferation of anti-body-forming cells and hemagglutinin production. The data obtained warrant an assumption that the part of B lymphocytes bearing aggregated antibodies are responsible for the synthesis of nonspecific immunoglobulins.
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