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  • Title: Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia.
    Author: Guglielmi P, Preud'Homme JL.
    Journal: Clin Exp Immunol; 1980 Jul; 41(1):136-40. PubMed ID: 6969148.
    Abstract:
    Peripheral blood lymphocytes from five untreated patients affected with B-derived chronic lymphocytic leukaemia were stimulated by protein A from Staphylococcus aureus. A very strong response (with stimulation indexes as high as 182 and percentages of blast cells as high as 90%) was found in all patients. Lymphocyte marker studies showed that the responding cells were T cells. These results and the well known abnormalities of lymphocyte response to other mitogens suggest a disbalance of T lymphocyte subpopulations in B-CLL.
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