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  • Title: Specific serum protein levels in women using intrauterine contraceptive device.
    Author: Wiedermann D, Kríz J, Cídl K.
    Journal: Czech Med; 1980; 3(3):239-47. PubMed ID: 6969168.
    Abstract:
    The report is concerned with the levels of 17 specific serum proteins in 46 women using plastic nonmedicated intrauterine contraceptive device (IUCD) Dana-Super. Blood samplings were carried out three times: just before the IUCD introduction, 30 and 54 weeks after the insertion of IUCD. The following proteins except haptoglobin were quantitatively determined by radial immunodiffusion: prealbumin, albumin, orosomucoid, alpha 1-antitrypsin, ceruloplasmin, alpha 2HS-glycoprotein, alpha 2-macroglobulin, hemopexin, C3-component, transferrin, beta 2-glycoprotein I, C-reactive protein and immunoglobulins IgG, IgA, IgM and IgD. Moderately increased values were found for alpha 2HS-glycoprotein and beta 2-glycoprotein I in sera taken 30 weeks after the insertion of IUCD. AT the same time the augmentation of alpha 1-antitrypsin was established. This might be evoked by the raised protease activity in biological fluids of genital region. The raise in consequence of IUCD application of transferrin and the decrease of haptoglobin at the first postinsertion examination and the decrease of hemopexin and albumin at the second may be associated with higher menstrual bleeding followed by iron deficiency. All other proteins as well as the acute phase proteins showed only minor if any differences as compared with the corresponding start values. Similarly, there is no evidence of a systemic immunoglobulin response to IUCD use. The report is concerned with the levels of 17 specific serum proteins in 46 women using plastic nonmedicated Dana-Super IUDs. Blood samplings were carried out 3 times: just before IUD introduction, and 30 and 54 weeks after the insertion of IUD. The following proteins except haptoglobin were quantitatively determined by radial immunodiffusion: prealbumin, albumin, orosomucoid, alpha1-antitrypsin, ceruloplasmin, alpha2-HS-glycoprotein, alpha2-macroglobulin, hemopexin, C3-component, transferrin, beta2-glycoprotein 1, C-reactive protein and immunoglobulins IgG, IgA, IgM and IgD. Moderately increased values were found for alpha2HS-glycoprotein and beta2-glycoprotein 1 in sera taken 30 weeks after the insertion of IUD. At the same time the augmentation of alpha1-antitrypsin was established. This might be evoked by the raised protease activity in biological fluids of genital region. The raise in consequence of IUD application of transferrin and the decrease of haptoglobin at the 1st postinsertion examination and the decrease of hemopexin and albumin at the 2nd may be associated with higher menstrual bleeding followed by iron deficiency. All other proteins as well as the acute phase proteins showed only minor if any differences as compared with the corresponding start values. Similarly, there is no evidence of a systemic immunoglobulin response to IUD use.
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