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  • Title: Production of human hybridomas secreting antibodies to measles virus.
    Author: Croce CM, Linnenbach A, Hall W, Steplewski Z, Koprowski H.
    Journal: Nature; 1980 Dec 04; 288(5790):488-9. PubMed ID: 6969366.
    Abstract:
    Monoclonal antibodies against a variety of antigens can be produced using techniques of somatic cell hybridization between cells of rodent myeloma lines and B cells derived from animals immunized against a given antigen. However, because of the monoclonal antibodies secreted by these hybridomas are of rodent origin, their use in human immunotherapy is limited. Thus the production of B-cell hybrids that secrete human monoclonal antibodies may be of considerable value. We have hybridized a hypoxanthine phosphoribosyl transferase (HPRT)-deficient human B-cell line derived from a patient suffering from multiple myeloma with peripheral lymphocytes obtained from a patient with subacute sclerosing panencephalitis (SSPE). These hybridomas were found to secrete human IgM specific for measles virus nucleocapsids.
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