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  • Title: Concanavalin A induces a T-cell dependent activation of human tonsil B cells in vitro.
    Author: Vitiello A, Nespoli L, Lanzavecchia A, Maccario R, Ugazio AG.
    Journal: Thymus; 1980 Jan; 1(4-5):215-23. PubMed ID: 6969473.
    Abstract:
    Tonsillar lymphocytes cultured for 7 days in serum-supplemented RPMI-1640 medium were stimulated with Con A or PWM. IgM production was assessed by a hemagglutination inhibition assay. IgM was produced after Con A as well as PWM stimulation. Our data show that T-cell irradiation and/or addition of small numbers of T cells to the responding B-cell population facilitate(s) IgM synthesis. In particular in Con A-stimulated cultures the T-cell number is critical in regulating the appearance of suppressor effects. The results are discussed in terms of the various subpopulations possibly involved in the response to these mitogens.
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