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  • Title: Study on the effects of L-5HTP on the stages of sleep in man as evaluated by using sleep deprivation.
    Author: Nakazawa Y, Hasuzawa H, Kotorii T, Ohkawa T, Sakurada H, Nonaka K, Dainoson K.
    Journal: Folia Psychiatr Neurol Jpn; 1980; 34(2):83-7. PubMed ID: 6970155.
    Abstract:
    The effects of L-5HTP 200 mg on the EEG sleep pattern were investigated in normal subjects. When L-5HTP 200 mg was orally administered, only % S1 significantly decreased in comparison with the baseline. There was no change in any sleep stage on the first recovery night. On the second recovery night, % S1 significantly decreased, while % SR increased significantly. SWS did not show any change. The effects of L-5HTP 200 mg were investigated on the first recovery night after one night of sleep deprivation. SWS significantly increased on the first recovery night when a placebo was given, while this rebound increase of SWS disappeared and % S2 significantly increased on the first recovery night when L-5HTP was given. % SR significantly increased on the next night after the L-5HTP night.
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