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  • Title: Study of lymphocyte subpopulations in patients with systemic lupus erythematosus. In vitro effect of levamisole on T-lymphocyte population.
    Author: Pozsonyi T, Jakab L, Fehér J.
    Journal: Allergol Immunopathol (Madr); 1980; 8(5):553-8. PubMed ID: 6970515.
    Abstract:
    Peripheral blood lymphocytes and the "in vitro' changes of the T-cell count after levamisole treatment were studied in twenty-two patients with systemic lupus erythematosus and in eighteen normal controls using E-rosette assay to quantify T-cells and EAC-assay to quantify B-lymphocytes. T-cell count was significantly lower in the patient group compared with the control group. B-cell numbers did not change significantly. The decrease of the T-cell count was accompanied by an increase of the null-cell number in patient groups. The levamisole treatment "in vitro' produced an increase in the active-T and total T-lymphocyte counts and led to the decrease of null-cell numbers. These data confirm the available evidence that levamisole "in vitro' may induce the maturation of immature T-lymphocytes in SLE.
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