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  • Title: The ototoxic potential of netilmicin compared with amikacin. An animal study in guinea pigs.
    Author: Wersäll J.
    Journal: Scand J Infect Dis Suppl; 1980; Suppl 23():104-13. PubMed ID: 6970981.
    Abstract:
    The potential ototoxicity of netilmicin and amikacin was compared in guinea pigs. When the toxicity in animals is determined two parameters should be discussed: Dose related comparison of ototoxicity and a comparison related to the antibacterial potency. None of the netilmicin test groups (50-100 mg/kg body weight) showed a higher percentage of degenerated hair cells than the control group. Even the individual animals showed a sensory cell damage within the control animal range. With the antibacterial potency taken into account, a dose three times higher was given to the animals treated with amikacin than to those treated with netilmicin. The amikacin group of animals showed a high percentage of degenerated hair cells under these conditions.
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