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  • Title: [Prevention of postoperative Candida endomycoses. Candida colonization and Candida antibodies in patients undergoing cardiovascular surgery].
    Author: Ansorg R, Krause C, Neitzel J.
    Journal: Chirurg; 1981 Apr; 52(4):231-6. PubMed ID: 6971741.
    Abstract:
    Of 23 patients undergoing heart surgery and 11 patients undergoing vessel surgery 26 (76%) are colonized with Candida albicans on admission to hospital. Postoperatively the yeast quantity in the mucocutaneous flora remains nearly constant in both groups. However, during the 2nd-3rd week after operation 21 heart surgery patients and 3 vessel surgery patients developed a significant rise in Candida antibodies in the Ig-classes G, M and/or A. Eight weeks after surgery the IgM-antibodies once again reached preoperative values in 14 of 16 patients; the IgG- and IgA-antibodies, however, tend to be of longer persistent. The antibody response is most probably due to Candida invasion via tracheal traumatization by prolonged intubation. Persistent elevation of IgM-antibodies indicates preventive antifungal therapy.
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