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  • Title: [Combined oral retinoid and PUVA therapy in the treatment of psoriasis and psoriatic arthropathy (author's transl)].
    Author: Thivolet J, Robart S, Vignon E.
    Journal: Ann Dermatol Venereol; 1981; 108(2):131-7. PubMed ID: 6972721.
    Abstract:
    Combined oral retinoid (RO 10.9359) and PUVA therapy were given to 107 patients with psoriasis, 9 of whom had psoriatic arthropathy. Treatment was started with the retinoid at a dose of 1 mg/kg day and PUVA therapy added after 2 weeks. No other treatment was given. In 100 patients the combined therapy achieved clearing of the lesions, including scalp lesions, in a shorter time and with less total joules/cm2 than a group treated by PUVA alone. The remaining 7 patients were not responding to PUVA alone but achieved clearing when the retinoid was added. Five patients out of 9 with psoriatic arthropathy responded to the combined therapy. Predictable mild side-effects from the retinoid were encountered. The teratogenic risk of retinoid therapy is emphasized. The value of combined retinoid-PUVA therapy in psoriasis is discussed.
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