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  • Title: Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy.
    Author: Morelli M, Porceddu ML, Imperato A, Di Chiara G.
    Journal: Brain Res; 1981 Aug 03; 217(2):375-9. PubMed ID: 6972799.
    Abstract:
    Bilateral kainate-induced lesions of the substantia nigra prevented or dramatically reduced the catalepsy produced by haloperidol. In contrast, infusion of 1 or 4 micrograms 6-OHDA in the medial forebrain bundle, which decreased striatal DA by 30% and 80% respectively, failed to affect or actually potentiated haloperidol catalepsy. Since intranigral kainate, in contrast to 6-OHDA, destroys pars reticulata neurons it appears that these neurons are essential for the expression of haloperidol-catalepsy.
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