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  • Title: Plasmodium chabaudi-infection of mice: effects of chloroquine and mefloquine. Inhibition of ornithine decarboxylase activity.
    Author: Königk E, Mirtsch S, Putfarken B, Abdel-Rasoul S.
    Journal: Tropenmed Parasitol; 1981 Jun; 32(2):73-6. PubMed ID: 6973226.
    Abstract:
    Ornithine decarboxylase activity was inhibited in Plasmodium chabaudi-infected red cells of mice treated with chloroquine, mefloquine, primaquine and floxacrine. In vitro experiments on membrane-bound enzymes performed with intact P. chabaudi-infected red cells and corresponding ghost preparations showed a stimulation of NA+K+-ATP'ase and Ca2+Mg2+-ATP'ase activity in the presence of chloroquine, mefloquine and floxacrine.
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