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  • Title: Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor.
    Author: Heldin CH, Wasteson A, Fryklund L, Westermark B.
    Journal: Science; 1981 Sep 04; 213(4512):1122-3. PubMed ID: 6973821.
    Abstract:
    The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.
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