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  • Title: Misonidazole enhancement of radiation-induced growth delay in rat rhabdomyosarcoma tumours exposed to accelerated carbon and neon ions.
    Author: Tenforde TS, Curtis SB, Tenforde SD, Parr SS, Crabtree KE, Flynn MJ, Howard J, Lyman JT.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1981 Aug; 40(2):117-29. PubMed ID: 6974143.
    Abstract:
    The response of a rat rhabdomyosarcoma tumour was assessed by measurements of radiation-induced growth delay resulting from administration of the hypoxic cell sensitizer misonidazole in combination with single and fractionated doses of X-rays and charged-particle radiation. Enhancement ratios of 1.8--2.1 were obtained following single doses of misonidazole (500 mg/kg i.p.) and 225 kV X-rays. Single doses of misonidazole with either carbon-ion or neon-ion radiation in the 4 cm extended-peak ionization region led to enhancement ratios of 1.2--1.3. When combined misonidazole (300 mg/kg i.p.) and X-ray treatments were given in four daily fractions, the enhancement ratios decreased to 1.2--1.5. However, a four-fraction schedule using either carbon-ion or neon-ion radiation in combination with misonidazole gave enhancement ratios of 1.1--1.3, which are similar to the values obtained for single-dose schedules with the sensitizer and charged-particle radiation.
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