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  • Title: Influence of age and sex on serum complement components in children.
    Author: Roach B, Kim Y, Jerome E, Michael AF.
    Journal: Am J Dis Child; 1981 Oct; 135(10):918-20. PubMed ID: 6975036.
    Abstract:
    Concentrations of eight complement components were determined on sera from 419 healthy children (198 boys and 221 girls) aged from 1 to 19 years. A significant correlation between concentration and age for all complement components (C1q, C1s, C4, C3, C5, factor B, properdin, and C1 inhibitor) was observed for girls; in the male population, a significant correlation was present only for C1q, C4, C3, C5, and properdin. The presence of a significant relationship to age suggests that this variable must be considered in establishing normal values of serum complement for children.
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