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  • Title: Lymphocyte function and cell-mediated immunity in pigs with experimentally induced African swine fever.
    Author: Sanchez-Vizcaino JM, Slauson DO, Ruiz-Gonzalvo F, Valero F.
    Journal: Am J Vet Res; 1981 Aug; 42(8):1335-41. PubMed ID: 6975049.
    Abstract:
    Twenty-five pigs inoculated with African Swine fever virus were studied for the development of changes in lymphocyte numbers and function. The results indicated that lymphopenia and decreased percentage of circulating T-lymphocytes occurred as early as 7 days after the pigs were inoculated. These were accompanied by depressed lymphocyte function, as measured by mitogen- or antigen-induced blastogenesis. There were proportionately greater decreases in T-lymphocyte numbers and function than were found for B-lymphocytes. Studies of phagocytic cell function revealed decreased phagocytic function for peripheral blood monocytes and unchanged (normal) neutrophil function. Depressed T-lymphocyte function occurred in pigs with acute and subacute infections, indicating depression of cellular immune function.
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