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  • Title: Definition of the high-risk acute lymphoblastic leukemia patient by immunological phenotyping with monoclonal antibodies.
    Author: Zipf TF, Fox RI, Dilley J, Levy R.
    Journal: Cancer Res; 1981 Nov; 41(11 Pt 2):4786-9. PubMed ID: 6975160.
    Abstract:
    An accurate method of classification of the surface membrane characteristics of blast cells from patients with acute lymphoblastic leukemia would allow a more definitive study of the nature of this disease. Monoclonal antibodies have been produced to the surface antigens of leukemic blasts form a patient with high-risk acute lymphoblastic leukemia. Two antibodies of interest were obtained from this immunization. These two, in combination with a monoclonal antibody with anti-Ia specificity, have been used to obtain surface phenotypes for patients with childhood acute lymphoblastic leukemia. Preliminary results indicate that the definition of a high-risk group, using these antibodies, possible.
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